Anti-MAGED1 Antibody

MAGED1 (also known as NRAGE or Dlxin-1) is a member of the type II melanoma antigen (MAGE) family of protein. MAGED1 can interact with the nerve growth factor receptor p75NTR, antagonize the association of p75NTR with TrkA, inhibit cell cycle progression, and facilitate p75NTR-mediated apoptosis (PMID: 10985348) . It has been reported that MAGED1 binds Dlx5 and regulates its transcriptional function. In vivo, MAGED1 binds not only Dlx5 but also Dlx7 and Msx2 and forms homomultimers (PMID: 11084035) . MAGED1 knockout mice show depressive behavior and impairments of circadian rhythm (PMID: 20300063; 23314527) . Three transcript variants encoding two different isoforms (86kDa and 92 kDa) have been found for the gene of MAGED1.