Anti-MYLIP Antibody
Boster Bio Anti-MYLIP Antibody catalog # A05031. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
E3 ubiquitin-protein ligase MYLIP;6.3.2.-; Inducible degrader of the LDL-receptor; Idol; Myosin regulatory light chain interacting protein; MIR; MYLIP; BZF1, IDOL; BM-023, PP5242
Gene Name
MYLIP
UniProt
Q8WY64
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human MYLIP. AA range:161-210
Tissue Specificity
Ubiquitously expressed. .
Applications
WB, IHC, IF, ELISA
Purification
Immunogen affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
49910 MW
Gene Name Synonym
E3 ubiquitin-protein ligase MYLIP
Subcellular Location
Cytoplasm . Cell membrane ; Peripheral membrane protein .
Isotype
IgG
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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