Anti-LEMD3 Antibody
Boster Bio Anti-LEMD3 Antibody (Catalog # A04957) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Product Specifications
Background
LEMD3 (LEM domain-containing 3) is a lem-domain containing protein, also known as MAN1, whose loss of function results in disorders characterized by osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis. LEMD3 is an inner nuclear membrane protein that interacts with BMP and activin-TGF-beta receptor-activated Smads and antagonizes TGF-beta signaling in human cells.
Synonyms
MAN1, MAN1, Inner nuclear membrane protein Man1, LEM domain-containing protein 3
Gene Name
LEMD3
UniProt
Q9Y2U8
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
At least three isoforms of LEMD3 are known to exist; this antibody will detect all isoforms. LEMD3 antibody is predicted to not cross-react with LEMD1 and LEMD2
Immunogen
LEMD3 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human LEMD3. The immunogen is located within the last 50 amino acids of LEMD3.
Clonality
Polyclonal
Tissue Specificity
Heart, brain, placenta, lung, liver and skeletal muscle.
Applications
ELISA, WB, IHC-P, IF
Field of Research
Signal Transduction
Purification
LEMD3 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.
Storage Conditions
Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight
99997 MW
Gene Name Synonym
LEM domain containing 3
Subcellular Location
Nucleus inner membrane
Protein Name
LEM domain containing 3
Isotype
IgG
Contents
LEMD3 Antibody is supplied in PBS containing 0.02% sodium azide.
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