Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-LEMD3 Antibody

Boster Bio Anti-LEMD3 Antibody (Catalog # A04957) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

LEMD3 (LEM domain-containing 3) is a lem-domain containing protein, also known as MAN1, whose loss of function results in disorders characterized by osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis. LEMD3 is an inner nuclear membrane protein that interacts with BMP and activin-TGF-beta receptor-activated Smads and antagonizes TGF-beta signaling in human cells.

Synonyms

MAN1, MAN1, Inner nuclear membrane protein Man1, LEM domain-containing protein 3

Gene Name

LEMD3

UniProt

Q9Y2U8

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

At least three isoforms of LEMD3 are known to exist; this antibody will detect all isoforms. LEMD3 antibody is predicted to not cross-react with LEMD1 and LEMD2

Immunogen

LEMD3 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human LEMD3. The immunogen is located within the last 50 amino acids of LEMD3.

Clonality

Polyclonal

Tissue Specificity

Heart, brain, placenta, lung, liver and skeletal muscle.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction

Purification

LEMD3 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.

Storage Conditions

Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

99997 MW

Gene Name Synonym

LEM domain containing 3

Subcellular Location

Nucleus inner membrane

Protein Name

LEM domain containing 3

Isotype

IgG

Contents

LEMD3 Antibody is supplied in PBS containing 0.02% sodium azide.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Sheep Clusterin (CLU) Protein
abx167805-01 50 µg

Sheep Clusterin (CLU) Protein

Ask
View Details
Sheep Clusterin (CLU) Protein
abx167805-02 100 µg

Sheep Clusterin (CLU) Protein

Ask
View Details
Sheep Clusterin (CLU) Protein
abx167805-03 200 µg

Sheep Clusterin (CLU) Protein

Ask
View Details
Sheep Clusterin (CLU) Protein
abx167805-04 500 µg

Sheep Clusterin (CLU) Protein

Ask
View Details
Sheep Clusterin (CLU) Protein
abx167805-05 1 mg

Sheep Clusterin (CLU) Protein

Ask
View Details
Human Dipeptidyl Peptidase 10 (DPP10) ELISA Kit
EKN44861 96 Tests

Human Dipeptidyl Peptidase 10 (DPP10) ELISA Kit

Ask
View Details