Anti-Endonuclease 8-like 2 NEIL2 Antibody
Boster Bio Anti-Endonuclease 8-like 2 NEIL2 Antibody catalog # A04883. Tested in WB applications. This antibody reacts with Human, Rat.
Product Specifications
Synonyms
Endonuclease 8-like 2;3.2.2.-;4.2.99.18; DNA glycosylase/AP lyase Neil2; DNA- (apurinic or apyrimidinic site) lyase Neil2; Endonuclease VIII-like 2; Nei homolog 2; NEH2; Nei-like protein 2; NEIL2
Gene Name
NEIL2
UniProt
Q969S2
Host
Rabbit
Reactivity
Human, Rat
Immunogen
A synthetic peptide corresponding to residues in Human NEIL2
Clonality
Polyclonal
Tissue Specificity
Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles) . Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
36826 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Endonuclease 8-like 2
Subcellular Location
Nucleus
Protein Name
Endonuclease 8-like 2
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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