Anti-DNAJC3 Antibody
Boster Bio Anti-DNAJC3 Antibody catalog # A04805. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
DnaJ homolog subfamily C member 3; Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58; DNAJC3; P58IPK, PRKRI
Gene Name
DNAJC3
UniProt
Q13217
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human DNAJC3
Clonality
Polyclonal
Tissue Specificity
Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity) . Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
57580 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
DnaJ homolog subfamily C member 3
Subcellular Location
Endoplasmic reticulum .
Protein Name
DnaJ homolog subfamily C member 3
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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