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Anti-DNAJC3 Antibody

Boster Bio Anti-DNAJC3 Antibody catalog # A04805. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

DnaJ homolog subfamily C member 3; Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58; DNAJC3; P58IPK, PRKRI

Gene Name

DNAJC3

UniProt

Q13217

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to residues in Human DNAJC3

Clonality

Polyclonal

Tissue Specificity

Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity) . Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04805

Product MSDS

https://www.bosterbio.com/msds?sku=A04805

Observed Molecular Weight

57580 MW

Applications Notes

WB: 1:500-1:1000

Gene Name Synonym

DnaJ homolog subfamily C member 3

Subcellular Location

Endoplasmic reticulum .

Protein Name

DnaJ homolog subfamily C member 3

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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