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Anti-PRRX1 Antibody

Boster Bio Anti-PRRX1 Antibody (Catalog # A04774) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The paired related homeobox protein 1 (PRRX1) is a paired-type DNA-binding homeodomain that plays an important role as a key switch for neural cell lineage determination and is essential for development (1,2) . PRRX1 is expressed in a number of undifferentiated mesenchymal cells in mouse embryos and adults (3) . Mice with a disrupted PRRX1 gene show perinatal death with craniofacial and limb malformations (4) . Low PRRX1 expression levels were significantly associated with metastasis and poor prognosis of breast and colorectal cancer (5) .

Synonyms

Paired related homeobox 1, homeobox protein PHOX1, Paired mesoderm homeobox protein 1, PHOX1, PMX1, PRX1, PRX-1

Gene Name

PRRX1

UniProt

P54821

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

PRRX1 antibody is human, mouse and rat reactive. At least two isoforms of PRRX1 are known to exist; this antibody will detect both isoforms.

Immunogen

PRRX1 antibody was raised against a 19 amino acid peptide near the center of human PRRX1. The immunogen is located within amino acids 70 - 120 of PRRX1.

Clonality

Polyclonal

Applications

ELISA, WB

Field of Research

Cancer, Cell Cycle, Stem Cells

Purification

PRRX1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity) . .

Storage Conditions

PRRX1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

27296 MW

Gene Name Synonym

Paired related homeobox 1

Subcellular Location

Nucleus.

Prediction Reactivity

Chicken

Protein Name

Paired related homeobox 1

Isotype

IgG

Contents

PRRX1 antibody is supplied in PBS containing 0.02% sodium azide.

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