Anti-Transcription factor MafG MAFG Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691) . However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691) . Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691) . Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691) . Activates globin gene expression when associated with NFE2L2 (PubMed:11154691) . May be involved in signal transduction of extracellular H (+) (By similarity) .