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Anti-Sulfhydryl oxidase 1 QSOX1 Antibody

Boster Bio Anti-Sulfhydryl oxidase 1 QSOX1 Antibody (Catalog # A04549) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

The QSOX1 gene, also known as Quiescin Q6, is a fusion of two ancient genes: thioredoxin and ERV1. Its expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation (1) . The QSOX1 protein oxidizes sulfhydryl groups to form disulfide bonds in proteins. QSOX1 expression is induced by hypoxia (2) and appears to protect cells against oxidative stress-induced apoptosis (3) .

Synonyms

Quiescin Q6 sulfhydryl oxidase 1, Sulfhydryl oxidase 1, Q6, QSCN6

Gene Name

QSOX1

UniProt

O00391

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

QSOX1 antibody is human and mouse reactive. QSOX1 antibody is predicted to not cross-react with QSOX2.

Immunogen

QSOX1 antibody was raised against a 17 amino acid peptide near the center of human QSOX1. The immunogen is located within amino acids 360 - 410 of QSOX1.

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Cell Cycle, Cancer, Apoptosis

Purification

QSOX1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor- suppressing capabilities being involved in growth regulation.

Storage Conditions

QSOX1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

82578 MW

Gene Name Synonym

Quiescin Q6 sulfhydryl oxidase 1

Subcellular Location

Isoform 1: Golgi apparatus membrane; Single- pass membrane protein.

Prediction Reactivity

Rat

Protein Name

Quiescin Q6 sulfhydryl oxidase 1

Isotype

IgG

Contents

QSOX1 antibody is supplied in PBS containing 0.02% sodium azide.

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