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Anti-FKBP12 FKBP1A Antibody

Boster Bio Anti-FKBP12 FKBP1A Antibody (Catalog # A04492) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

FKBP, or FK506 binding protein, is a family of proteins that have prolyl isomerase activity and are related to the cyclophilins in function (1) . FKBP12, also called FKBP1, was originally identified as a target of FK506 and rapamycin activity and catalyzes the transition between cis and transproline residues critical for proper folding of proteins (2) . FKBP12 is an abundant, evolutionarily conserved cytoplasmic protein that is an important regulator of diverse array of cellular processes including T cell activation, entry into the cell cycle and intracellular calcium release (3-5) .

Synonyms

FKBP1, PKC12, PKCI2, FKBP12, PPIASE, FKBP-12, FKBP-1A, FKBP1, Peptidyl-prolyl cis-trans isomerase FKBP1A, 12 kDa FK506-binding protein, PPIase FKBP1A

Gene Name

FKBP1A

UniProt

P62942

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

FKBP12 antibody is human, mouse and rat reactive.

Immunogen

FKBP12 antibody was raised against an 18 amino acid peptide near the center of human FKBP12. The immunogen is located within the first 50 amino acids of FKBP12.

Clonality

Polyclonal

Applications

ELISA, WB, ICC, IF

Field of Research

Homeostasis, Immunology

Purification

FKBP12 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Storage Conditions

FKBP12 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

11951 MW

Gene Name Synonym

FK506 binding protein 1A, 12kDa

Subcellular Location

Cytoplasm, cytosol

Prediction Reactivity

Bovine, Rabbit

Protein Name

FK506 binding protein 1A, 12kDa

Isotype

IgG

Contents

FKBP12 Antibody is supplied in PBS containing 0.02% sodium azide.

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