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Anti-TRIM29 Antibody (Center)

Boster Bio Anti-TRIM29 Antibody (Center) (Catalog # A04472) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.

Synonyms

Tripartite motif-containing protein 29, Ataxia telangiectasia group D-associated protein, TRIM29, ATDC

Gene Name

TRIM29

UniProt

Q14134

Host

Rabbit

Reactivity

Human

Immunogen

This TRIM29 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the Central region of human TRIM29.

Clonality

Polyclonal

Tissue Specificity

Expressed in placenta, prostate and thymus.

Applications

WB

Field of Research

Cell Biology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

65835 Da

Applications Notes

WB: 1:1000

Subcellular Location

Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments

Prediction Reactivity

Mouse

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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