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Anti-HMGCS2 Antibody (C-term)

Boster Bio Anti-HMGCS2 Antibody (C-term) (Catalog # A04371-1) . Tested in WB, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human.

Product Specifications

Background

HMGCS2 belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting.

Synonyms

Hydroxymethylglutaryl-CoA synthase, mitochondrial, HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, HMGCS2

Gene Name

HMGCS2

UniProt

P54868

Host

Rabbit

Reactivity

Human

Immunogen

This HMGCS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 478-508 amino acids from the C-terminal region of human HMGCS2.

Clonality

Polyclonal

Tissue Specificity

Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas Very low expression in heart and skeletal muscle (PubMed:7893153, PubMed:21952825, PubMed:16940161) . Not detected in brain (PubMed:21952825) .

Applications

WB, Flow Cytometry, IHC-P

Field of Research

Cancer, Cardiovascular, Metabolism, Signal Transduction, Mitochondria

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

56635 Da

Subcellular Location

Mitochondrion {ECO:0000250|UniProtKB:P22791}.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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