Anti-TYSY Antibody (C-term)
Boster Bio Anti-TYSY Antibody (C-term) (Catalog # A04320-3) . Tested in Flow Cytometry, IF, IHC-P, WB application (s) . This antibody reacts with Human.
Product Specifications
Background
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.
Synonyms
Thymidylate synthase, TS, TSase, TYMS, TS
Gene Name
TYMS
UniProt
P04818
Host
Rabbit
Reactivity
Human
Immunogen
This TYSY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human TYSY.
Clonality
Polyclonal
Applications
Flow Cytometry, IF, IHC-P, WB
Field of Research
Metabolism, Mitochondria
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Catalyzes the reductive methylation of 2'-deoxyuridine 5'- monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1- carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
35716 Da
Subcellular Location
Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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