Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-TYSY Antibody (C-term)

Boster Bio Anti-TYSY Antibody (C-term) (Catalog # A04320-3) . Tested in Flow Cytometry, IF, IHC-P, WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

Synonyms

Thymidylate synthase, TS, TSase, TYMS, TS

Gene Name

TYMS

UniProt

P04818

Host

Rabbit

Reactivity

Human

Immunogen

This TYSY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human TYSY.

Clonality

Polyclonal

Applications

Flow Cytometry, IF, IHC-P, WB

Field of Research

Metabolism, Mitochondria

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Catalyzes the reductive methylation of 2'-deoxyuridine 5'- monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1- carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

35716 Da

Subcellular Location

Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

SKAP1 (Src Kinase-Associated Phosphoprotein 1, Src Family-Associated Phosphoprotein 1, Src Kinase-Associated Phosphoprotein of 55kD, SCAP1, SKAP55) (HRP)
227919 100 µg

SKAP1 (Src Kinase-Associated Phosphoprotein 1, Src Family-Associated Phosphoprotein 1, Src Kinase-Associated Phosphoprotein of 55kD, SCAP1, SKAP55) (HRP)

Ask
View Details
HPLC Column, C8-Low PH,5μm,120Å,3.0x150mm
13011430 1 PC

HPLC Column, C8-Low PH,5μm,120Å,3.0x150mm

Ask
View Details
Lycopersicon esculentum Lectin Biotin
MF-0112898-01 10 mg

Lycopersicon esculentum Lectin Biotin

Ask
View Details
Lycopersicon esculentum Lectin Biotin
MF-0112898-02 50 mg

Lycopersicon esculentum Lectin Biotin

Ask
View Details
RIP Double Nickase Plasmid (h)
sc-400377-NIC 20 µg

RIP Double Nickase Plasmid (h)

Ask
View Details
Brain Derived Basic Fibroblast Growth Factor (1-24)
HY-P3601-01 5 mg

Brain Derived Basic Fibroblast Growth Factor (1-24)

Ask
View Details