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Anti-ERAP2 Antibody

Boster Bio Anti-ERAP2 Antibody (Catalog # A04269) . Tested in ELISA, WB applications. This antibody reacts with Human.

Product Specifications

Background

The endoplasmic reticulum (ER) aminopeptidase 2 (ERAP2), a member of the peptidase M1 family, like the related protein ERAP1, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1,2) . Like ERAP1, ERAP2 is localized to the lumen of the ER and is thought to associate with ERAP1 as a heterodimer (1) . Both ERAP1 and ERAP2 have been linked to several human diseases ranging from infections to autoimmunity and cancer, and may play a role in the innate immune response (reviewed in 3) .

Synonyms

LRAP, L-RAP, LRAP, Endoplasmic reticulum aminopeptidase 2, Leukocyte-derived arginine aminopeptidase

Gene Name

ERAP2

UniProt

Q6P179

Host

Rabbit

Reactivity

Human

Cross Reactivity

ERAP2 antibody is human reactive. Multiple isoforms of ERAP2 are known to exist. ERAP2 antibody is predicted to not cross-react with ERAP1.

Immunogen

ERAP2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ERAP2. The immunogen is located within amino acids 110 - 160 of ERAP2 .

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. Highly expressed in spleen and leukocytes.

Applications

ELISA, WB

Field of Research

Innate Immunity

Purification

ERAP2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.

Storage Conditions

ERAP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

110462 MW

Gene Name Synonym

Endoplasmic reticulum aminopeptidase 2

Subcellular Location

Endoplasmic reticulum membrane

Prediction Reactivity

Bovine

Protein Name

Endoplasmic reticulum aminopeptidase 2

Isotype

IgG

Contents

ERAP2 Antibody is supplied in PBS containing 0.02% sodium azide.

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