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Anti-ANO6 Antibody (N-term)

Boster Bio Anti-ANO6 Antibody (N-term) (Catalog # A04251) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

May act as a calcium-activated chloride channel.

Synonyms

Anoctamin-6, Small-conductance calcium-activated nonselective cation channel, SCAN channel, Transmembrane protein 16F, ANO6, TMEM16F

Gene Name

ANO6

UniProt

Q4KMQ2

Host

Rabbit

Reactivity

Human

Immunogen

This ANO6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-96 amino acids from the N-terminal region of human ANO6.

Clonality

Polyclonal

Tissue Specificity

Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer

Applications

WB

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium- dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity) . Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

106165 Da

Applications Notes

WB: 1:1000

Subcellular Location

Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization according to PubMed:22075693

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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