Anti-C1QB Antibody (N-term)
Boster Bio Anti-C1QB Antibody (N-term) (Catalog # A04233-2) . Tested in Flow Cytometry, WB application (s) . This antibody reacts with Human.
Product Specifications
Background
C1QB is a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1.
Synonyms
Complement C1q subcomponent subunit B, C1QB
Gene Name
C1QB
UniProt
P02746
Host
Rabbit
Reactivity
Human
Immunogen
This C1QB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-81 amino acids from the N-terminal region of human C1QB.
Clonality
Polyclonal
Applications
Flow Cytometry, WB
Field of Research
Immunology, Neuroscience, Innate Immunity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca (2+) -dependent C1r (2) C1s (2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
26722 Da
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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