Anti-PACSIN2 Antibody (C-term)
Boster Bio Anti-PACSIN2 Antibody (C-term) (Catalog # A04211-1) . Tested in WB, IHC-P application (s) . This antibody reacts with Human, Mouse.
Product Specifications
Background
PACSIN may play a role in vesicle formation and transport. This protein homo- and hetero-aggregates with other PACSINs. It also binds dynamin 1, synaptojanin, synapsin 1 and the neural Wiskott-Aldrich syndrome protein (N-WASP) . The protein exhibits a cvesicle-like cytoplasmic distribution and is ubiquitously expressed. PACSIN is phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) . The protein contains 1 FCH domain and 1 SH3 domain.
Synonyms
Protein kinase C and casein kinase substrate in neurons protein 2, Syndapin-2, Syndapin-II, PACSIN2
Gene Name
PACSIN2
UniProt
Q9UNF0
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PACSIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 342-371 amino acids from the C-terminal region of human PACSIN2.
Clonality
Polyclonal
Tissue Specificity
Widely expressed.
Applications
WB, IHC-P
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Regulates the morphogenesis and endocytosis of caveolae (By similarity) . Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
55739 Da
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection Membrane, caveola. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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