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Anti-GRB14 (D123) Antibody

Boster Bio Anti-GRB14 (D123) Antibody catalog # A04177. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Growth factor receptor-bound protein 14; GRB14 adapter protein; GRB14

Gene Name

GRB14

UniProt

Q14449

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 90-102 of Human GRB14.

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.

Applications

IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR) . Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

60988 MW

Applications Notes

IHC: 1:50-1:200

Gene Name Synonym

Growth factor receptor-bound protein 14

Subcellular Location

Cytoplasm

Protein Name

Growth factor receptor-bound protein 14

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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