Anti-Myosin VIIa MYO7A Antibody
Boster Bio Anti-Myosin VIIa MYO7A Antibody catalog # A03915. Tested in WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Unconventional myosin-VIIa; MYO7A; USH1B
Gene Name
MYO7A
UniProt
Q13402
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide corresponding to residues in Human Myosin VIIa.
Clonality
Polyclonal
Tissue Specificity
Expressed in the pigment epithelium and the photoreceptor cells of the retina. Also found in kidney, liver, testis, cochlea, lymphocytes. Not expressed in brain.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity) . Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
254390 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Unconventional myosin-VIIa
Subcellular Location
Cytoplasm
Protein Name
Unconventional myosin-VIIa
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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