Anti-NSUN2 Antibody
Boster Bio Anti-NSUN2 Antibody catalog # A03878. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
TRNA (cytosine (34) -C (5) ) -methyltransferase;2.1.1.203; Myc-induced SUN domain-containing protein; Misu; NOL1/NOP2/Sun domain family member 2; Substrate of AIM1/Aurora kinase B; tRNA (cytosine-5-) -methyltransferase; tRNA methyltransferase 4 homolog; hTrm4; NSUN2; SAKI, TRM4
Gene Name
NSUN2
UniProt
Q08J23
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human NSUN2 (NP_060225.4) .
Clonality
Polyclonal
Tissue Specificity
Expressed in adult and fetal brain and in lymphoblastoid cells.
Applications
WB, IHC, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA (Leu) (CAA) precursors, and at positions 48, 49 and 50 of tRNA (Gly) (GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
86471 MW
Gene Name Synonym
TRNA (cytosine (34) -C (5) ) -methyltransferase
Subcellular Location
Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA.
Protein Name
TRNA (cytosine (34) -C (5) ) -methyltransferase
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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