Anti-HJURP Antibody
Boster Bio Anti-HJURP Antibody catalog # A03856. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Holliday junction recognition protein;14-3-3-associated AKT substrate; Fetal liver-expressing gene 1 protein; Up-regulated in lung cancer 9; HJURP; FAKTS, FLEG1
Gene Name
HJURP
UniProt
Q8NCD3
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from human protein at AA range: 80-160
Clonality
Polyclonal
Tissue Specificity
According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung.
Applications
WB, ELISA
Purification
HJURP antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/mL
Form
Liquid
Function
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
83539 MW
Gene Name Synonym
Holliday junction recognition protein
Subcellular Location
Nucleus, nucleolus. Chromosome, centromere. Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
Protein Name
Holliday junction recognition protein
Isotype
IgG
Contents
Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.
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