Anti-Kinetochore protein Nuf2 Nuf2 Antibody
Boster Bio Anti-Kinetochore protein Nuf2 Nuf2 Antibody catalog # A03788. Tested in WB, Flow Cytometry applications. This antibody reacts with Human.
Product Specifications
Synonyms
Kinetochore protein Nuf2; hNuf2; hNuf2R; hsNuf2; Cell division cycle-associated protein 1; NUF2; CDCA1, NUF2R
Gene Name
NUF2
UniProt
Q9BZD4
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant protein within human Nuf2 aa 1-200.
Clonality
Polyclonal
Applications
WB, Flow Cytometry
Purification
ProA affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814) . Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592) . The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
54304 MW
Gene Name Synonym
Kinetochore protein Nuf2
Subcellular Location
Nucleus. Chromosome, centromere, kinetochore. Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.
Protein Name
Kinetochore protein Nuf2
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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