Anti-CLAUDIN4 CLDN4 Antibody
Boster Bio Anti-CLAUDIN4 CLDN4 Antibody (Catalog # A03683) . Tested in ELISA, WB, IF applications. This antibody reacts with Human.
Product Specifications
Background
CLAUDIN4 is an integral membrane protein belonging to the claudin family, a family of cellular adhesion molecules that are components of tight junctions. CLAUDIN4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The CLAUDIN4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. CLAUDIN4 is frequently overexpressed in ovarian and other epithelial cancers.
Synonyms
CPER, CPE-R, CPETR, CPETR1, WBSCR8, hCPE-R, CPER, Claudin-4, Clostridium perfringens enterotoxin receptor
Gene Name
CLDN4
UniProt
O14493
Host
Rabbit
Reactivity
Human
Cross Reactivity
At least four isoforms of CLAUDIN4 are known to exist; CLAUDIN4 antibody will detect all four isoforms
Immunogen
Anti-CLAUDIN4 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human CLAUDIN4. The immunogen is located within the last 50 amino acids of CLAUDIN4.
Clonality
Polyclonal
Applications
ELISA, WB, IF
Field of Research
Cancer, Cell Cycle
Purification
CLAUDIN4 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Storage Conditions
CLAUDIN4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight
22077 MW
Gene Name Synonym
Claudin 4
Subcellular Location
Cell junction, tight junction
Prediction Reactivity
Bovine, Mouse, Rat
Protein Name
Claudin 4
Isotype
IgG
Contents
CLAUDIN4 Antibody is supplied in PBS containing 0.02% sodium azide.
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