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Anti-UPF2 Antibody

Boster Bio Anti-UPF2 Antibody catalog # A03627. Tested in WB, IHC applications. This antibody reacts with Human, Rat.

Product Specifications

Synonyms

Regulator of nonsense transcripts 2; Nonsense mRNA reducing factor 2; Up-frameshift suppressor 2 homolog; hUpf2; UPF2; KIAA1408, RENT2

Gene Name

UPF2

UniProt

Q9HAU5

Host

Rabbit

Reactivity

Human, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1153-1272 of human UPF2 (NP_542166.1) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) . Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

147810 MW

Gene Name Synonym

Regulator of nonsense transcripts 2

Subcellular Location

Cytoplasm, perinuclear region

Protein Name

Regulator of nonsense transcripts 2

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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