Anti-IL-37 Antibody
Boster Bio Anti-IL-37 Antibody (Catalog# A03607) . Tested in WB application (s) . This antibody reacts with Human.
Product Specifications
Synonyms
Interleukin-37; FIL1 zeta; IL-1X; Interleukin-1 family member 7; IL-1F7; Interleukin-1 homolog 4; IL-1H; IL-1H4; Interleukin-1 zeta; IL-1 zeta; Interleukin-1-related protein; IL-1RP1; Interleukin-23; IL-37; IL37; FIL1Z, IL1F7, IL1H4, IL1RP1
Gene Name
IL37
UniProt
Q9NZH6
Host
Rabbit
Reactivity
Human
Immunogen
Full length recombinant IL-37 protein
Clonality
Polyclonal
Tissue Specificity
In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
Applications
WB
Field of Research
Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation
Purification
Protein A Chromatography
Concentration
0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Form
Liquid
Function
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. .
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Observed Molecular Weight
24126 MW
Applications Notes
Western blot: 2-4 μg/ml
Gene Name Synonym
Interleukin-37
Subcellular Location
Cytoplasm, cytosol. Nucleus. Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
Protein Name
Interleukin-37
Isotype
Rabbit IgG
Contents
100 μ g in 200 μ l PBS containing 0.05% BSA and 0.05% sodium azide.
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