Anti-BRMS-1 (E43) Antibody
Boster Bio Anti-BRMS-1 (E43) Antibody catalog # A03587. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Breast cancer metastasis-suppressor 1; BRMS1
Gene Name
BRMS1
UniProt
Q9HCU9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 210-58 of Human BRMS-1.
Clonality
Polyclonal
Tissue Specificity
Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
Applications
IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
28461 MW
Applications Notes
IHC: 1:50-1:200
Gene Name Synonym
Breast cancer metastasis-suppressor 1
Subcellular Location
Nucleus. Cytoplasm. Predominantly nuclear.
Protein Name
Breast cancer metastasis-suppressor 1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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