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Anti-SOST Antibody (N-term)

Boster Bio Anti-SOST Antibody (N-term) (Catalog # A03551-1) . Tested in IHC-P-Leica, WB application (s) . This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Synonyms

Sclerostin, SOST

Gene Name

SOST

UniProt

Q9BQB4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-42 amino acids from the N-terminal region of human SOST.

Clonality

Polyclonal

Tissue Specificity

Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level) .

Applications

IHC-P-Leica, WB

Field of Research

Developmental Biology, Signal Transduction, Anti-Wnt-Pathway (plus Lgr5) Antibodies

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

24031 Da

Subcellular Location

Secreted, extracellular space, extracellular matrix

Prediction Reactivity

Bovine

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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