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Anti-DOCK 180 (K1692) Antibody

Boster Bio Anti-DOCK 180 (K1692) Antibody catalog # A03440. Tested in WB, IHC applications. This antibody reacts with Human, Rat.

Product Specifications

Synonyms

Dedicator of cytokinesis protein 1;180 kDa protein downstream of CRK; DOCK180; DOCK1

Gene Name

DOCK1

UniProt

Q14185

Host

Rabbit

Reactivity

Human, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 1660-1719 of Human DOCK 180.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829) . Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

215346 MW

Gene Name Synonym

Dedicator of cytokinesis protein 1

Subcellular Location

Cytoplasm . Membrane . Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. .

Protein Name

Dedicator of cytokinesis protein 1

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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