Anti-MMACHC Antibody
Boster Bio Anti-MMACHC Antibody catalog # A03398. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Methylmalonic aciduria and homocystinuria type C protein;1.16.1.-
Gene Name
MMACHC
UniProt
Q9Y4U1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human MMACHC
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Expressed at higher level in fetal liver. Also expressed in spleen, lymph node, thymus and bone marrow. Weakly or not expressed in peripheral blood leukocytes.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Catalyzes the reductive dealkylation of cyanocobalamin to cob (II) alamin, using FAD or FMN as cofactor and NADPH as cosubstrate (PubMed:19700356, PubMed:21697092, PubMed:22642810) . Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin (PubMed:19801555, PubMed:22642810, PubMed:25809485) . Under anaerobic conditions cob (I) alamin is the first product; it is highly reactive and is converted to aquocob (II) alamin in the presence of oxygen (PubMed:19801555) . Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives (PubMed:21071249) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
31728 MW
Applications Notes
WB: 1:500-1:2000
Gene Name Synonym
Methylmalonic aciduria and homocystinuria type C protein
Subcellular Location
Cytoplasm
Protein Name
Methylmalonic aciduria and homocystinuria type C protein
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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