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Anti-CALCR Antibody (C-term)

Boster Bio Anti-CALCR Antibody (C-term) (Catalog # A03322-1) . Tested in WB, IF, Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

CALCR is a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis.

Synonyms

Calcitonin receptor, CT-R, CALCR

Gene Name

CALCR

UniProt

P30988

Host

Rabbit

Reactivity

Human

Immunogen

This CALCR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-474 amino acids of human CALCR.

Clonality

Polyclonal

Applications

WB, IF, Flow Cytometry

Field of Research

Cancer, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

55345 Da

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Curated Selection

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