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Anti-LMX1B Antibody

Boster Bio Anti-LMX1B Antibody (Catalog # A03296) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The LIM homeobox transcription factor 1B (LMX1B) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1B regulates mid-hindbrain patterning; LMX1B-null mice embryos have a severe reduction in the number of midbrain dopaminergic neurons compared to wild-type. While LMX1B appears to be important for both the development and the survival of dopamine neurons, the related LMX1A is crucial for the differentiation of these cells. However, LMX1A and LMX1B function cooperatively to regulated the proliferation, specification and differentiation of midbrain dopaminergic neuronal progenitors.

Synonyms

NPS1, LMX1.2, LIM homeobox transcription factor 1-beta

Gene Name

LMX1B

UniProt

O60663

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least three isoforms are known to exist. This antibody is predicted to not cross-react with LMX1A.

Immunogen

Rabbit polyclonal LMX1B antibody was raised against a 17 amino acid peptide near the carboxy terminus of human LMX1B. The immunogen is located within amino acids 280 - 330 of LMX1B.

Clonality

Polyclonal

Tissue Specificity

Expressed in most tissues. Highest levels in testis, thyroid, duodenum, skeletal muscle, and pancreatic islets.

Applications

ELISA, WB

Field of Research

Stem Cells

Purification

LMX1B Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.

Storage Conditions

LMX1B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

44917 MW

Gene Name Synonym

LIM homeobox transcription factor 1, beta

Subcellular Location

Nucleus

Protein Name

LIM homeobox transcription factor 1, beta

Isotype

IgG

Contents

LMX1B Antibody is supplied in PBS containing 0.02% sodium azide.

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