Anti-Poly [ADP-ribose] polymerase 2 PARP2 Antibody
Boster Bio Anti-Poly [ADP-ribose] polymerase 2 PARP2 Antibody catalog # A03270. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Poly [ADP-ribose] polymerase 2; PARP-2; hPARP-2;2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 2; ARTD2; NAD (+) ADP-ribosyltransferase 2; ADPRT-2; Poly[ADP-ribose] synthase 2; pADPRT-2; PARP2; ADPRT2, ADPRTL2
Gene Name
PARP2
UniProt
Q9UGN5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to Human PARP2.
Clonality
Polyclonal
Tissue Specificity
Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus.
Applications
WB
Purification
ProA affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768) . This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231) . Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
66206 MW
Applications Notes
WB: 1:1000-1:2000
Gene Name Synonym
Poly [ADP-ribose] polymerase 2
Subcellular Location
Nucleus
Protein Name
Poly [ADP-ribose] polymerase 2
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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