Anti-LIR-1 LILRB1 Antibody
Boster Bio Anti-LIR-1 LILRB1 Antibody catalog # A03208. Tested in WB, IHC applications. This antibody reacts with Human.
Product Specifications
Synonyms
Leukocyte immunoglobulin-like receptor subfamily B member 1; LIR-1; Leukocyte immunoglobulin-like receptor 1; CD85 antigen-like family member J; Immunoglobulin-like transcript 2; ILT-2; Monocyte/macrophage immunoglobulin-like receptor 7; MIR-7; CD85j; LILRB1; ILT2, LIR1, MIR7
Gene Name
LILRB1
UniProt
Q8NHL6
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from the N-terminal region of human LILRB1. AA range:21-70
Tissue Specificity
Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected on a low percentage of T-cells and natural killer (NK) cells. .
Applications
WB, IHC
Purification
Immunogen affinity purified
Concentration
1 mg/mL
Form
Liquid
Function
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
70819 MW
Gene Name Synonym
Leukocyte immunoglobulin-like receptor subfamily B member 1
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Isotype
IgG
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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