Anti- (Mouse) Tdgf1 Antibody (N-term)

Boster Bio Anti- (Mouse) Tdgf1 Antibody (N-term) (Catalog # A03105) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Mouse.

Product Specifications

Background

Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

Synonyms

Teratocarcinoma-derived growth factor, Cripto growth factor, Epidermal growth factor-like Cripto protein, Tdgf1, Cripto

Gene Name

Tdgf1

UniProt

P51865

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Tdgf1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 37-70 amino acids from the N-terminal region of mouse Tdgf1.

Clonality

Polyclonal

Tissue Specificity

Expressed at low level in specific organs of the adult animal such as spleen, heart, lung and brain. During gastrulation, expressed in the forming mesoderm. In later stages of the developing heart, expression is restricted to the truncus arteriosus

Applications

WB, Flow Cytometry

Field of Research

Developmental Biology, Signal Transduction, Stem Cells

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by Tmem8a modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

18754 Da

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000250|UniProtKB:P13385}. Note=Released from the cell membrane by GPI cleavage. {ECO:0000250|UniProtKB:P13385}