Anti-PID MTA2 Antibody
Boster Bio Anti-PID MTA2 Antibody (Catalog # A03073) . Tested in ELISA, WB, ICC, IF, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex. PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis. PID/MTA2 is ubiquitously expressed in human tissues.
Synonyms
PID, MTA1L1, PID, Metastasis-associated protein MTA2, Metastasis-associated 1-like 1, MTA1-L1 protein
Gene Name
MTA2
UniProt
O94776
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
PID antibody is predicted to not cross-react with MTA2
Immunogen
PID antibody was raised against a 17 amino acid peptide near the carboxy terminus of human PID. The immunogen is located within the last 50 amino acids of PID.
Clonality
Polyclonal
Tissue Specificity
Widely expressed.
Applications
ELISA, WB, ICC, IF, IHC-P
Field of Research
Apoptosis
Purification
PID Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
Storage Conditions
PID antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight
75023 MW
Gene Name Synonym
Metastasis associated 1 family, member 2
Subcellular Location
Nucleus
Protein Name
Metastasis associated 1 family, member 2
Isotype
IgG
Contents
PID Antibody is supplied in PBS containing 0.02% sodium azide.
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
