Anti-EPHA1 (phospho-Y605) Antibody
Boster Bio Anti-EPHA1 (phospho-Y605) Antibody catalog # A03024Y605. Tested in WB applications. This antibody reacts with Human, Rat.
Product Specifications
Synonyms
Ephrin type-A receptor 1; hEpha1;2.7.10.1; EPH tyrosine kinase; EPH tyrosine kinase 1; Erythropoietin-producing hepatoma receptor; Tyrosine-protein kinase receptor EPH; EPHA1; EPH, EPHT, EPHT1
Gene Name
EPHA1
UniProt
P21709
Host
Rabbit
Reactivity
Human, Rat
Immunogen
A synthetic peptide corresponding to residues in Human EPHA1 around the phosphorylation site of Tyr605.
Clonality
Polyclonal
Tissue Specificity
Overexpressed in several carcinomas.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
108127 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Ephrin type-A receptor 1
Subcellular Location
Cell membrane
Protein Name
Ephrin type-A receptor 1
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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