Anti-Cyclin H (E311) CCNH Antibody
Boster Bio Anti-Cyclin H (E311) CCNH Antibody catalog # A03013. Tested in IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Cyclin-H; MO15-associated protein; p34; p37; CCNH
Gene Name
CCNH
UniProt
P51946
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 300-350 of Human Cyclin H.
Clonality
Polyclonal
Applications
IHC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
37643 MW
Gene Name Synonym
Cyclin-H
Subcellular Location
Nucleus.
Protein Name
Cyclin-H
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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