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Anti-ERK3 (phospho-S189) MAPK6 Antibody

Boster Bio Anti-ERK3 (phospho-S189) MAPK6 Antibody catalog # A03011S189. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Mitogen-activated protein kinase 6; MAP kinase 6; MAPK 6;2.7.11.24; Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97; p97-MAPK; MAPK6; ERK3, PRKM6

Gene Name

MAPK6

UniProt

Q16659

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human ERK3 around the phosphorylation site of Serine 189.

Clonality

Polyclonal

Tissue Specificity

Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

82681 MW

Applications Notes

WB: 1:500-1:2000

Gene Name Synonym

Mitogen-activated protein kinase 6

Subcellular Location

Cytoplasm . Nucleus . Translocates to the cytoplasm following interaction with MAPKAPK5. .

Protein Name

Mitogen-activated protein kinase 6

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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