Anti-R-Spondin RSPO1 Monoclonal Antibody
Boster Bio Anti-R-Spondin RSPO1 Monoclonal Antibody catalog # A02857. Tested in WB, ELISA applications. This antibody reacts with Human.
Product Specifications
Synonyms
R-spondin-1; Roof plate-specific spondin-1; hRspo1; RSPO1
Gene Name
RSPO1
UniProt
Q2MKA7
Host
Mouse
Reactivity
Human
Immunogen
Purified recombinant fragment of R-spondin1 expressed in E. Coli.
Clonality
Monoclonal
Clone
Clone: 7A6
Tissue Specificity
Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. .
Applications
WB, ELISA
Purification
Affinity purification
Concentration
1 mg/mL
Form
Liquid
Function
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
28959 MW
Gene Name Synonym
R-spondin-1
Subcellular Location
Secreted . Nucleus . Seems to mainly localize to nucleoli. .
Isotype
IgG1
Contents
Ascitic fluid containing 0.03% sodium azide.
Conjugate
Unconjugated
Curated Selection
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