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Anti-5'-3' exoribonuclease 1 XRN1 Antibody

Boster Bio Anti-5'-3' exoribonuclease 1 XRN1 Antibody catalog # A02855. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

5'-3' exoribonuclease 1;3.1.13.-; Strand-exchange protein 1 homolog; XRN1; SEP1

Gene Name

XRN1

UniProt

Q8IZH2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.

Applications

WB, ELISA

Purification

XRN1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity) . Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

194107 MW

Gene Name Synonym

5'-3' exoribonuclease 1

Subcellular Location

Cytoplasm

Protein Name

5'-3' exoribonuclease 1

Isotype

IgG

Contents

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.

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