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Anti-HP1 alpha CBX5 Monoclonal Antibody

Boster Bio Anti-HP1 alpha CBX5 Monoclonal Antibody catalog # A02780. Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat, Bovine, Dog, Pig.

Product Specifications

Synonyms

Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha; CBX5; HP1A

Gene Name

CBX5

UniProt

P45973

Host

Mouse

Reactivity

Human, Mouse, Rat, Bovine, Dog, Pig

Immunogen

Purified recombinant human HP1α protein fragments expressed in E.coli.

Clonality

Monoclonal

Applications

WB, IF

Purification

Protein A purified

Concentration

1 mg/mL

Form

Liquid

Function

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) . Can interact with lamin-B receptor (LBR) . This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

22225 MW

Gene Name Synonym

Chromobox protein homolog 5

Subcellular Location

Nucleus . Chromosome . Chromosome, centromere . Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.

Contents

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

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