Anti-Granzyme A GZMA Antibody
Boster Bio Anti-Granzyme A GZMA Antibody catalog # A02779. Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Granzyme A;3.4.21.78; CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Granzyme-1; Hanukkah factor; H factor; HF; GZMA; CTLA3, HFSP
Gene Name
GZMA
UniProt
P12544
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length Human GZMA.
Clonality
Polyclonal
Applications
WB, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
28999 MW
Gene Name Synonym
Granzyme A
Subcellular Location
Isoform alpha: Secreted. Cytoplasmic granule.
Protein Name
Granzyme A
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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