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Anti-ARHGEF7/Beta Pix Antibody

Boster Bio Anti-ARHGEF7/Beta Pix Antibody (Catalog# A02764) . Tested in WB, IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

ARHGEF7; COOL1; KIAA0142; P85SPR; PAK3BP; PIXB; Nbla10314; Rho guanine nucleotide exchange factor 7; Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85

Gene Name

ARHGEF7

UniProt

Q14155

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A peptide derived from human ARHGEF7. Immunogen sequence location: 311 - 360

Clonality

Polyclonal

Applications

WB, IHC, ICC, IF, ELISA

Field of Research

Actin, etc., Cancer, Cytoskeleton, Cytoskeleton/ECM, G Protein Signaling, Microfilaments, Signal Transduction, Signaling Pathway, Small G Proteins

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity) . May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

90012 MW

Gene Name Synonym

Rho guanine nucleotide exchange factor 7

Subcellular Location

Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, lamellipodium. Detected at cell adhesions. A small proportion is detected at focal adhesions.

Isotype

Rabbit IgG

Contents

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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