Anti-PRKRA Antibody
Boster Bio Anti-PRKRA Antibody catalog # A02744. Tested in WB, IHC applications. This antibody reacts with Mouse.
Product Specifications
Synonyms
Interferon-inducible double-stranded RNA-dependent protein kinase activator A; PKR-associated protein X; PKR-associating protein X; Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator; PRKRA; PACT, RAX; HSD-14, HSD14
Gene Name
PRKRA
UniProt
O75569
Host
Rabbit
Reactivity
Mouse
Immunogen
Recombinant fusion protein of human PRKRA/PACT (NP_003681.1) .
Clonality
Polyclonal
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity) .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
34404 MW
Gene Name Synonym
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Subcellular Location
Cytoplasm, perinuclear region. Cytoplasm.
Protein Name
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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