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Anti-DNA Ligase III LIG3 Antibody

Boster Bio Anti-DNA Ligase III LIG3 Antibody catalog # A02741. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

DNA ligase 3;6.5.1.1 ; DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3; LIG3

Gene Name

LIG3

UniProt

P49916

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from DNA Ligase III . at AA range: 110-190

Tissue Specificity

Testis, thymus, prostate and heart.

Applications

WB, ELISA

Purification

Immunogen affinity purified

Concentration

1 mg/mL

Form

Liquid

Function

Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

112907 MW

Gene Name Synonym

DNA ligase 3

Subcellular Location

Isoform 1: Mitochondrion . Contains an N-terminal mitochondrial transit peptide. .

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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