Anti-Crk2 (phospho-Y221) Antibody
Boster Bio Anti-Crk2 (phospho-Y221) Antibody catalog # A02533Y221. Tested in WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK
Gene Name
CRK
UniProt
P46108
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic phosphopeptide derived from human Crk2 around the phosphorylation site of Tyrosine 221.
Clonality
Polyclonal
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
33831 MW
Applications Notes
WB: 1:500-1:1000
Gene Name Synonym
Adapter molecule crk
Subcellular Location
Cytoplasm . Cell membrane . Translocated to the plasma membrane upon cell adhesion. .
Protein Name
Adapter molecule crk
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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