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Anti-Crk2 (phospho-Y221) Antibody

Boster Bio Anti-Crk2 (phospho-Y221) Antibody catalog # A02533Y221. Tested in WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK

Gene Name

CRK

UniProt

P46108

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic phosphopeptide derived from human Crk2 around the phosphorylation site of Tyrosine 221.

Clonality

Polyclonal

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

33831 MW

Applications Notes

WB: 1:500-1:1000

Gene Name Synonym

Adapter molecule crk

Subcellular Location

Cytoplasm . Cell membrane . Translocated to the plasma membrane upon cell adhesion. .

Protein Name

Adapter molecule crk

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

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