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Anti-NTRK3 Antibody (Center)

Boster Bio Anti-NTRK3 Antibody (Center) (Catalog # A02502-1) . Tested in Flow Cytometry, WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Receptor for neurotrophin-3 (NT-3) . This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.

Synonyms

NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, NTRK3, TRKC

Gene Name

NTRK3

UniProt

Q16288

Host

Rabbit

Reactivity

Human

Immunogen

This NTRK3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 393-426 amino acids from the Central region of human NTRK3.

Clonality

Polyclonal

Tissue Specificity

Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain

Applications

Flow Cytometry, WB

Field of Research

Cancer, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

94428 Da

Subcellular Location

Membrane; Single-pass type I membrane protein.

Prediction Reactivity

Monkey, Pig

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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