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Anti-CASK Antibody

Boster Bio Anti-CASK Antibody (Catalog # A02468) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

CASK (Calcium/calmodulin-dependent serine protein kinase), a conserved multi-domain scaffolding protein, belongs to a MAGUK (membrane-associated guanylate kinase homologs) subfamily and is involved in cell junction organization, tumor suppression and signaling. It is characterized by a novel domain structure that consists of a calcium/calmodulin-dependent protein kinase domain followed by PDZ, SH3 and guanylate kinase-like (GUK) domains. CASK is ubiquitously expressed and significantly greater in brain where it is thought to be involved in signaling at neuronal synapses. CASK interacts with CASKINs and defects in CASK are the cause of mental retardation X-linked CASK-related.

Synonyms

CMG, FGS4, LIN2, TNRC8, CAGH39, CAMGUK, MICPCH, MRXSNA, Peripheral plasma membrane protein CASK, Protein lin-2 homolog, hCASK

Gene Name

CASK

UniProt

O14936

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least six alternatively spliced transcript variants have been observed.

Immunogen

CASK antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CASK. The immunogen is located within amino acids 760 - 810 of CASK.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.

Applications

ELISA, WB, IF

Field of Research

Neuroscience

Purification

CASK Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

Storage Conditions

CASK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

105123 MW

Gene Name Synonym

Calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Subcellular Location

Nucleus . Cytoplasm . Cell membrane ; Peripheral membrane protein .

Protein Name

Calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Isotype

IgG

Contents

CASK Antibody is supplied in PBS containing 0.02% sodium azide.

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