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Anti-TLE1 Antibody (N-term)

Boster Bio Anti-TLE1 Antibody (N-term) (Catalog # A02460-1) . Tested in IF, WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Synonyms

Transducin-like enhancer protein 1, E (Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1, TLE1

Gene Name

TLE1

UniProt

Q04724

Host

Rabbit

Reactivity

Human

Immunogen

This TLE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 187-221 amino acids from the N-terminal region of human TLE1.

Clonality

Polyclonal

Tissue Specificity

In all tissues examined, mostly in brain, liver and muscle

Applications

IF, WB

Field of Research

Signal Transduction, Stem Cells, Anti-Wnt-Pathway (plus Lgr5) Antibodies

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF- 1- and HES1-mediated transcriptional repression (By similarity) . The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

83201 Da

Subcellular Location

Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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